On the various strategies for cancer treatment with the Plasma Gun

Abstract : This contribution consists in the state of art on the in vivo experiments performed for yet with the plasma source developed for years at GREMI, so called Plasma Gun (PG) [1], for cancer treatment following various approaches and plasma delivery strategies. Beyond the first demonstration for in vivo tumor regression achieved with the FE-DBD [2] on subcutaneous heterotopic brain tumors and successive plasma-induced biological process analysis [3], PG has been used in various tumor treatment protocols. Tumor regression following PG treatment was proven for orthotopic pancreatic carcinoma alone or in combination with chemotherapy delivery [4], but also for orthotopic colorectal tumor models. While these two later experiments emphasized the possibility to deliver single or multiple plasma fractions on fragile organs, a more relevant protocol for therapeutic applications was also recently reported [5] dealing with mouse lung tissue inflammation induced through endoscopic PG plasma delivery. These lung inflammation studies have proven the potentialities of plasma delivery using a micro and flexible plasma endoscope based on PG technology performed with very moderate gas flow rate. Finally, a different approach based on in situ locoregional plasma-induced tissue oxygenation was recently reported opening new opportunities for combined plasma and chemotherapeutic or radiotherapeutic strategies. This work is supported through APR Région Centre PLASMED and PLASMEDNORM and ANR 2010 BLAN 093003. References [1] E. Robert, V. Sarron, D. Riès, S. Dozias, M. Vandamme and J.M. Pouvesle Plasma Sources Sci. Technol. 21 034017 (2012). [2] M. Vandamme, E. Robert, S. Pesnel, E. Barbosa, S. Dozias, J. Sobilo, S. Lerondel, A. Le Pape and J.M. Pouvesle Plasma Process. Polym.7:264-73 (2010). [3] M. Vandamme, E. Robert, S. Lerondel, V. Sarron, D. Riès, S. Dozias, J. Sobilo, D. Gosset, C. Kieda, B. Legrain, J.M. Pouvesle and A. Le Pape Int J Cancer. doi: 10.1002/ijc.26252 (2011). [4] L. Brullé, M. Vandamme, D. Riès, E. Martel, E. Robert, S. Lerondel, V. Trichet, S. Richard, J.M. Pouvesle and A. Le Pape Plos one 7 (12) e52653 (2012). [5] E. Robert, M. Vandamme, L. Brullé, S. Lerondel, A. Le Pape, V. Sarron, D. Riès, T. Darny, S. Dozias, G. Collet, C. Kieda and J.M. Pouvesle Clinical Plasma Medicine, http://dx.doi. org/10.1016/j.cpme.2013.10.002i (2013). [6] G. Collet, E. Robert, A. Lenoir, M. Vandamme, T. Darny, S. Dozias, C. Kieda and J.M. Pouvesle accepted in Plasma Sources Sci. Technol. (2014).
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Eric Robert, Marc Vandamme, Guillaume Collet, Claudine Kieda, Jean Michel Pouvesle. On the various strategies for cancer treatment with the Plasma Gun. 1st International Workshop on Plasma for Cancer Treatment (IWPCT1), Mar 2014, Washington DC, United States. ⟨hal-01056965⟩



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