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Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.

Abstract : Transgenic macaques would allow to study brain function and diseases. We report that an engineered adeno-associated virus serotype 9 variant (scAAV9) injected intravenously in newborn rhesus macaques results in efficient, exclusively-neuronal and widespread transduction of the brain. The present data pave the way to large-scale genetic modelling of brain diseases in the rhesus macaque.
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https://hal.archives-ouvertes.fr/hal-01053467
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Benjamin Dehay, Deniz Dalkara, Sandra Dovero, Qin Li, Erwan Bezard. Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.. Sci Rep, 2012, 2, pp.253. ⟨10.1038/srep00253⟩. ⟨hal-01053467⟩

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