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Genome scans for detecting footprints of local adaptation using a Bayesian factor model.

Abstract : : There is a considerable impetus in population genomics to pinpoint loci involved in local adaptation. A powerful approach to find genomic regions subject to local adaptation is to genotype numerous molecular markers and look for outlier loci. One of the most common approaches for selection scans is based on statistics that measure population differentiation such as FST . However there are important caveats with approaches related to FST because they require grouping individuals into populations and they additionally assume a particular model of population structure. Here we implement a more flexible individual-based approach based on Bayesian factor models. Factor models capture population structure with latent variables called factors, which can describe clustering of individuals into populations or isolation-by-distance patterns. Using hierarchical Bayesian modeling, we both infer population structure and identify outlier loci that are candidates for local adaptation. In order to identify outlier loci, the hierarchical factor model searches for loci that are atypically related to population structure as measured by the latent factors. In a model of population divergence, we show that it can achieve a 2-fold or more reduction of false discovery rate compared to the software BayeScan or compared to an FST approach. We show that our software can handle large datasets by analyzing the SNPs of the Human Genome Diversity Project. The Bayesian factor model is implemented in the open-source PCAdapt software.
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https://hal.archives-ouvertes.fr/hal-01053023
Contributor : Michael Gb Blum Connect in order to contact the contributor
Submitted on : Tuesday, July 29, 2014 - 1:52:29 PM
Last modification on : Wednesday, October 20, 2021 - 12:47:25 AM

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Nicolas Duforet-Frebourg, Eric Bazin, Michael G B Blum. Genome scans for detecting footprints of local adaptation using a Bayesian factor model.. Molecular Biology and Evolution, Oxford University Press (OUP), 2014, epub ahead of print. ⟨10.1093/molbev/msu182⟩. ⟨hal-01053023⟩

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