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Communication Dans Un Congrès Année : 2013

Different patterns of gene body DNA methylation in ESC and EpiSC

Luc Jouneau
Marks Hendrik
  • Fonction : Auteur
Anita Kaan
  • Fonction : Auteur
Henk Stunnenberg
  • Fonction : Auteur
Alice Jouneau

Résumé

DNA methylation is an epigenetic mark usually associated with repression of expression. However, this has been mainly shown when DNA methylation is localized in the promoter regions (see also abstract from "Veillard et al". With the possibility to generate whole-genome methylomes, it has become evident that most DNA methylated regions were within gene body, but no consistent roles have been yet assigned to this type of methylation, at least in mammalian species. To get insight into this phenomenon, we have compared the whole-genome methylomes of two types of mouse pluripotent cell lines, ESCs and EpiSCs. These two types of cells are considered as representing two states of pluripotency, the naïve and primed state and they display a number of phenotypic and functional differences. At first glance, their methylome did not differ significantly, however, a closer examination reveals striking differences of methylation in 5'UTR and 3'UTR as well as CpG island enrichment. Our study aims at investigating the functional significance of these differences.
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Dates et versions

hal-01019566 , version 1 (07-07-2014)

Identifiants

  • HAL Id : hal-01019566 , version 1
  • PRODINRA : 253003

Citer

Luc Jouneau, Marks Hendrik, Anne-Clémence Veillard, Anita Kaan, Henk Stunnenberg, et al.. Different patterns of gene body DNA methylation in ESC and EpiSC. Conférence Jacques Monod Méthylation et déméthylation de l'ADN, Centre National de la Recherche Scientifique (CNRS). FRA., Sep 2013, Roscoff, France. 1 p. ⟨hal-01019566⟩
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