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V. =. @bullet, 6708(13)Å, ? = 75647 g cm ?3 , ? = 4.815 mm ?1 . The structure was solved by direct methods using the SIR97 program [46], and then refined with full-matrix least-square methods based on F 2 (SHELXL-97) [47] with the aid of the WINGX [48]program. The contribution of the disordered solvents to the calculated structure factors was estimated following the BYPASS algorithm [49], implemented as the SQUEEZE option in PLATON [50]. A new data set, free of solvent contribution, was then used in the final refinement. All non-hydrogen atoms were refined with anisotropic atomic displacement parameters. H atoms were finally included in their calculated positions. A final refinement on F 2 with 8064 unique intensities and 361 parameters converged at ?R(F 2 )) for 2888 observed reflections with I > 2? (I) Crystallographic data for the structure of 3a in this paper have been deposited in the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 938832. Copies of the data can be obtained, free of charge, on application to CCDC, ?g heparin/mL. Buffer B 50 mM MgCl 2 , 90 mM NaCl, p.50, 1771.

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