New 5-ylidene rhodanine derivatives based on the dispacamide A model.

Abstract : A practical approach for the preparation of ([Formula: see text]) 5-ylidene rhodanine derivatives bearing the (4,5-dihalogeno-pyrrol-2-yl)carbamoyl fragment of dispacamide A is reported. The new compounds were obtained in good yields (19-88 %) by Knoevenagel condensation according to a solution-phase microwave dielectric heating protocol in the presence of organic bases (piperidine, TEA, and AcONa) from a set of [Formula: see text]-substituted rhodanines 2(a-i). The ten synthetic products 3(a-j) have been synthesized with a [Formula: see text]-geometry about their exocyclic double bond and the structure of one of these compounds (3) was confirmed by a single X-ray diffraction analysis. The new ([Formula: see text]) 5-ylidene rhodanine derivatives 3(a-j) were tested against eight protein kinases.
Type de document :
Article dans une revue
Molecular Diversity, Springer Verlag, 2014, 18 (2), pp.375-88. 〈10.1007/s11030-014-9509-7〉
Domaine :
Liste complète des métadonnées

Littérature citée [49 références]  Voir  Masquer  Télécharger

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01017003
Contributeur : Laurent Jonchère <>
Soumis le : mardi 1 juillet 2014 - 15:51:21
Dernière modification le : vendredi 16 novembre 2018 - 02:20:16

Fichier

New_5-ylidene_rhodanine_deriva...
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Solène Guihéneuf, Ludovic Paquin, François Carreaux, Emilie Durieu, Thierry Roisnel, et al.. New 5-ylidene rhodanine derivatives based on the dispacamide A model.. Molecular Diversity, Springer Verlag, 2014, 18 (2), pp.375-88. 〈10.1007/s11030-014-9509-7〉. 〈hal-01017003〉

Partager

Métriques

Consultations de la notice

490

Téléchargements de fichiers

977