Trigocherrierin A, a potent inhibitor of chikungunya virus replication.

Mélanie Bourjot (1) , Pieter Leyssen , Johan Neyts (2) , Vincent Dumontet (1) , Marc Litaudon (1)

1 ICSN - Institut de Chimie des Substances Naturelles
2 Rega Institute for Medical Research [Leuven, België]

Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A-C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC₅₀ = 0.6 ± 0.1 µM, SI = 71.7).

Domaines: Chimie organique

Mélanie Bourjot, Pieter Leyssen, Johan Neyts, Vincent Dumontet, Marc Litaudon. Trigocherrierin A, a potent inhibitor of chikungunya virus replication.. Molecules, 2014, 19 (3), pp.3617-3627. ⟨10.3390/molecules19033617⟩. ⟨hal-01011997⟩