Emergence of Zaire Ebola Virus Disease in Guinea - Preliminary Report.

Sylvain Baize (1) , Delphine Pannetier (1) , Lisa Oestereich (2) , Toni Rieger (2) , Lamine Koivogui (3) , N'Faly Magassouba (4) , Barrè Soropogui (4) , Mamadou Saliou Sow (5) , Sakoba Keïta (3) , Hilde de Clerck (6) , Amanda Tiffany (7, 8, 9) , Gemma Dominguez (9) , Mathieu Loua (10) , Alexis Traoré (11) , Moussa Kolié (12) , Emmanuel Roland Malano (13) , Emmanuel Heleze (13) , Anne Bocquin (1) , Stephane Mély (1) , Hervé Raoul (1) , Valérie Caro (8) , Dániel Cadar (2) , Martin Gabriel (2) , Meike Pahlmann (2) , Dennis Tappe (2) , Jonas Schmidt-Chanasit (2) , Benido Impouma (14) , Abdoul Karim Diallo (13) , Pierre Formenty (15) , Michel van Herp (6) , Stephan Günther (2)

1 UBIVE - Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections
2 BNITM - Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany]
3 INSP - Institut National de Santé Publique [Conakry, Guinée]
4 Laboratoire des Fièvres Hémorragiques en Guinée
5 Donka National Hospital
6 Médecins Sans Frontières Belgique
7 Epicentre [Paris] [Médecins Sans Frontières]
8 PF8 - Génotypage des Pathogènes et Santé Publique (Plate-forme)
9 MSF - Médecins sans Frontières [Genève]
10 Direction Régionale de la Santé de Nzérékoré
11 Direction Préfectorale de la Santé de Guéckédou
12 Hôpital Préfectoral de Guéckédou
13 World Health Organization [Guinée]
14 World Health Organization
15 OMS / WHO - Organisation Mondiale de la Santé / World Health Organization Office

: In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known EBOV strains from the Democratic Republic of Congo and Gabon. Epidemiologic investigation linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December 2013. This study demonstrates the emergence of a new EBOV strain in Guinea.

Domaines: Sciences du Vivant [q-bio]

Sylvain Baize, Delphine Pannetier, Lisa Oestereich, Toni Rieger, Lamine Koivogui, et al.. Emergence of Zaire Ebola Virus Disease in Guinea - Preliminary Report.. New England Journal of Medicine, 2014, epub ahead of print. ⟨10.1056/NEJMoa1404505⟩. ⟨hal-01011799⟩