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FANCM Limits Meiotic Crossovers

Abstract : The number of meiotic crossovers (COs) is tightly regulated within a narrow range, despite a large excess of molecular precursors. The factors that limit COs remain largely unknown. Here, using a genetic screen in Arabidopsis thaliana, we identified the highly conserved FANCM helicase, which is required for genome stability in humans and yeasts, as a major factor limiting meiotic CO formation. The fancm mutant has a threefold-increased CO frequency as compared to the wild type. These extra COs arise not from the pathway that accounts for most of the COs in wild type, but from an alternate, normally minor pathway. Thus, FANCM is a key factor imposing an upper limit on the number of meiotic COs, and its manipulation holds much promise for plant breeding.
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https://hal.archives-ouvertes.fr/hal-01004174
Contributor : Archive Ouverte Prodinra <>
Submitted on : Wednesday, June 11, 2014 - 11:03:28 AM
Last modification on : Wednesday, June 16, 2021 - 3:48:25 AM

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Wayne Crismani, Chloé Girard, Nicole Froger, Monica Pradillo, Juan Luis Santos, et al.. FANCM Limits Meiotic Crossovers. Science, American Association for the Advancement of Science, 2012, 336 (6088), pp.1588 - 1590. ⟨10.1126/science.1220381⟩. ⟨hal-01004174⟩

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