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Hibernoma: a clinical model for exploring the role of brown adipose tissue in the regulation of body weight?

Abstract : Context: Hibernoma is a rare benign tumor histologically similar to brown adipose tissue. Some studies reported weight loss in patients with this tumor; however, the mechanisms have never been investigated. Objective: The purpose of this study is to explore the impact of hibernoma resection on the whole-body metabolism. Patient and Methods: A 68-year-old woman was examined after a weight loss of 10 kg in 6 months. Body composition, food intake, physical activity, blood levels of thyroid hormones, and lipid profile were assessed before surgery and during 1 year after surgery. The patient's resting energy expenditure (REE) over time was compared to a control group of 18 matched healthy volunteers. Results: Within 1 year after hibernoma resection, the patient gained 15 kg of body weight. This was associated with fat mass gain (+41%), mainly in the abdominal region (+48%). The patient also developed hepatic nonalcoholic steatosis, mild hypertriglyceridemia, and reduced levels of high-density lipoproteins. REE increased during the dynamic phase of weight gain, compared to the presurgery measurement, and returned to baseline after 1 year. Food intake was increased by 37.5% 6 weeks after resection of the hibernoma and returned to baseline values within 6 months. Conclusions: In our study conditions, hibernoma did not alter REE, but weight gain did. Specific physical activities and dietetic follow-ups are suggested for those patients to prevent excess fat mass gain and metabolic disorders after hibernoma resection. More studies should focus on hibernoma mechanisms inducing weight loss. Affiliations
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Submitted on : Thursday, June 5, 2014 - 5:31:26 PM
Last modification on : Tuesday, March 17, 2020 - 2:50:32 AM

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Emilie Gadéa, Emilie Thivat, Rodolphe Paulon, Florence Mishellany, Pierre Gimbergues, et al.. Hibernoma: a clinical model for exploring the role of brown adipose tissue in the regulation of body weight?. Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2014, 99 (1), pp.1-6. ⟨10.1210/jc.2013-2829⟩. ⟨hal-01002236⟩



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