Quantitative trait loci for resistance to infection in sheep using a live Salmonella Abortusovis vaccine

Isabelle Lantier (1) , Carole Moreno-Romieux Moreno (2) , Patricia Berthon (1) , Guillaume Salle Sallé (2) , Frederique Pitel (3) , Laurent L. Schibler (4) , A.V. A. Gautier-Bouchardon (5) , R. R. Boivin (1) , Jean Louis J. L. Weisbecker (6) , Dominique Francois (2) , Jacques J. Bouix (2) , Edmond E. Cribiu (4) , Jean Michel J. M. Elsen (2) , Frédéric F. Lantier (1)

1 UMR ISP - Infectiologie et Santé Publique
2 SAGA - Station d'Amélioration Génétique des Animaux
3 LGC - Laboratoire de Génétique Cellulaire
4 GABI - Génétique Animale et Biologie Intégrative
5 LERAPP
6 BOURGES - Domaine expérimental Bourges-La Sapinière

Quantitative trait loci (QTL) mapping for susceptibility to a Salmonella Abortusovis vaccinal strain was performed using an experimental design involving 30 Romane sheep sire families (1216 progenies). Nine QTL corresponding to bacterial load, weight variations and antibody response criteria were mapped on eight chromosomes, including the major histocompatibility complex area on chromosome 20. Surprisingly, none was found to be significant in the SLC11A1 region (formerly NRAMP1) that has been shown to influence Salmonella susceptibility in other species.

Mots clés: genetic resistance; quantitative trait loci; sheep; salmonella abortusovis

Domaines: Bactériologie

Isabelle Lantier, Carole Moreno-Romieux Moreno, Patricia Berthon, Guillaume Salle Sallé, Frederique Pitel, et al.. Quantitative trait loci for resistance to infection in sheep using a live Salmonella Abortusovis vaccine. Animal Genetics, 2012, 43 (5), pp.632-635. ⟨10.1111/j.1365-2052.2011.02291.x⟩. ⟨hal-01000399⟩