Selective monomethylation of primary amines with simple electrophiles.

Thomas Lebleu , Xiaolu Ma , Jacques Maddaluno (1) , Julien Legros

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

Direct monomethylation of primary amines with methyl triflate was achieved with high selectivity (up to 96%). The key point of this single methyl transfer stems from the use of HFIP as the solvent that interferes with amines and avoids overmethylation.

Domaines: Chimie organique

Thomas Lebleu, Xiaolu Ma, Jacques Maddaluno, Julien Legros. Selective monomethylation of primary amines with simple electrophiles.. Chemical Communications, 2014, 50 (15), pp.1836-1838. ⟨10.1039/c3cc48997c⟩. ⟨hal-00996920⟩