Netamines H-N, Tricyclic Alkaloids from the Marine Sponge Biemna laboutei and Their Antimalarial Activity.

Abstract : Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 μM.
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https://hal.archives-ouvertes.fr/hal-00996830
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Submitted on : Tuesday, May 27, 2014 - 9:21:13 AM
Last modification on : Monday, September 2, 2019 - 9:42:59 AM

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Emmanuelle Gros, Ali Al-Mourabit, Marie-Thérèse Martin, Jonathan Sorres, Jean Vacelet, et al.. Netamines H-N, Tricyclic Alkaloids from the Marine Sponge Biemna laboutei and Their Antimalarial Activity.. Journal of Natural Products, American Chemical Society, 2014, 77 (4), pp.818-823. ⟨10.1021/np4009283⟩. ⟨hal-00996830⟩

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