Thermally controlled decarboxylative [4 + 2] cycloaddition between alkoxyoxazoles and acrylic acid: expedient access to 3-hydroxypyridines.

Laurie-Anne Jouanno (1) , Vincent Tognetti (1) , Laurent Joubert (1) , Cyrille Sabot (1) , Pierre-Yves Renard (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

A modified Kondrat'eva cycloaddition involving an unprecedented thermally controlled metal-free decarboxylative aromatization affords an expedient access to natural 3-hydroxypyridine/piperidine systems.

Domaines: Chimie organique

Laurie-Anne Jouanno, Vincent Tognetti, Laurent Joubert, Cyrille Sabot, Pierre-Yves Renard. Thermally controlled decarboxylative [4 + 2] cycloaddition between alkoxyoxazoles and acrylic acid: expedient access to 3-hydroxypyridines.. Organic Letters, 2013, 15 (10), pp.2530-2533. ⟨10.1021/ol4010195⟩. ⟨hal-00996416⟩