Zn impacts Cu coordination to amyloid-beta, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity

Bruno Alies (1) , Isabelle Sasaki (1) , O. Proux (2) , S. Sayen (3) , E. Guillon (3) , Peter Faller (1) , Christelle Hureau (1)

1 LCC - Laboratoire de chimie de coordination
2 OSUG - Observatoire des Sciences de l'Univers de Grenoble
3 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312

Combined coordination of Zn-II and Cu-I or Cu-II to the amyloid-beta peptide has been investigated using XANES, EPR and NMR spectroscopies. While ZnII does alter Cu-II binding to A beta, this has no effect on (A beta)Cu induced ROS production and associated cell toxicity.

Mots clés: active metal-ions; prion protein; precursor protein; binding-sites; a-beta; copper; zinc; disease; environment; complexes

Bruno Alies, Isabelle Sasaki, O. Proux, S. Sayen, E. Guillon, et al.. Zn impacts Cu coordination to amyloid-beta, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity. Chemical Communications, 2013, 49 (12), pp.1214-1216. ⟨10.1039/c2cc38236a⟩. ⟨hal-00992985⟩