Integrated circuits and systems interacting with biology: exploring mechanisms and therapeutic closed loop paradigms

Abstract : The challenges in the domain medical research have an evident societal impact. Designing embedded systems for health is an opportunity to combine advances in micro- or nano-technology and issues in biology related to physiological or pathological mechanisms, and finally contribute to novel therapeutic ways. The concept of "hybrid" system can be used to materialize and decompose the scheme of interaction between the biological tissue ("bioware") and the artificial electronics part ("hardware" and "software"), around the interface (electrode or array of electrodes). Challenges exist at each stage of this hybrid system: unknown physiological mechanisms, interface optimization, front-end circuits either for recording or stimulating, implementation of the processing algorithms. When the objective is furthermore to elaborate an autonomous and bi-directional interaction between living tissues and electronics, other questions arise like management of stimulation artifact, real-time processing and auto-adaptation. A review of these multiple challenges will be proposed, taking examples in current research projects on DBS for Parkinson disease, electrophysiology of the pancreas to sense the insulin need, hybridation of living and artificial neural networks in case of spinal cord injury.
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Conference papers
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https://hal.archives-ouvertes.fr/hal-00986325
Contributor : Noëlle Lewis <>
Submitted on : Friday, May 2, 2014 - 10:54:35 AM
Last modification on : Thursday, January 11, 2018 - 6:21:09 AM

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  • HAL Id : hal-00986325, version 1

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Noëlle Lewis. Integrated circuits and systems interacting with biology: exploring mechanisms and therapeutic closed loop paradigms. SEMBA & BioPro International Workshop, Special Session Novel prosthetic Devices, 2013, Taiwan. ⟨hal-00986325⟩

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