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A novel bioelectronic glucose sensor to process distinct electrical activities of pancreatic beta-cells

Abstract : Glucose sensors have considerably improved and facilitated therapy for type 1 diabetes. Pancreatic beta-cells have been shaped during evolution as biological glucose sensors and should integrate a number of physiological relevant signals. Moreover, a biosensor based on these cells may serve for their non-invasive and long-term characterization, for drug research, tissue engineering and pre-transplantation quality control. beta-cells alter their electrical activity upon exposure to glucose and physiological hormones. We have used these properties to design a biosensor. To this end extracellular signals were recorded from these cells on multi-electrode arrays and we describe here the presence of slow and rapid oscillations, both modulated by glucose. Especially slow oscillations are very robust and have an excellent signal/noise ratio. Signal processing functions were designed to separate the two activities to extract and analyze relevant parameters. These parameters correlate very well with either increasing or decreasing glucose concentrations. An electronic device is under construction, based on an embedded FPGA capable of processing multiple channels in parallel. This device shall be used as a portable and real-time biosensor regulating insulin delivery from a pump.
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Quang Vinh Nguyen, Anton Caro, Matthieu Raoux, Adam Quotb, Jean-Baptiste Floderer, et al.. A novel bioelectronic glucose sensor to process distinct electrical activities of pancreatic beta-cells. 35th Annual International Conference of the IEEE EMBS, Jul 2013, Japan. pp.172 - 175, ⟨10.1109/EMBC.2013.6609465⟩. ⟨hal-00980774⟩

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