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miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain.

Abstract : microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that were coinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that strain-specific differences in miR-146a modulation were in part mediated by the rhoptry kinase, ROP16. Remarkably, we found that miR-146a deficiency led to better control of parasite burden in the gut and most likely of early parasite dissemination in the brain tissue, resulting in the long-term survival of mice.
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https://hal.archives-ouvertes.fr/hal-00980026
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Dominique Cannella, Marie-Pierre Brenier-Pinchart, Laurence Braun, Jason M van Rooyen, Alexandre Bougdour, et al.. miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain.. Cell Reports, Elsevier Inc, 2014, 6 (5), pp.928-37. ⟨10.1016/j.celrep.2014.02.002⟩. ⟨hal-00980026⟩

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