miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Reports Année : 2014

miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain.

Résumé

microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that were coinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that strain-specific differences in miR-146a modulation were in part mediated by the rhoptry kinase, ROP16. Remarkably, we found that miR-146a deficiency led to better control of parasite burden in the gut and most likely of early parasite dissemination in the brain tissue, resulting in the long-term survival of mice.
Fichier principal
Vignette du fichier
2014_cannella_cell_1.pdf (2.08 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-00980026 , version 1 (27-05-2020)

Identifiants

Citer

Dominique Cannella, Marie-Pierre Brenier-Pinchart, Laurence Braun, Jason M van Rooyen, Alexandre Bougdour, et al.. miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain.. Cell Reports, 2014, 6 (5), pp.928-37. ⟨10.1016/j.celrep.2014.02.002⟩. ⟨hal-00980026⟩
243 Consultations
30 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More