In Situ Preparation of a Multifunctional Chiral Hybrid Organic-Inorganic Catalyst for Asymmetric Multicomponent Reactions

Pilar Garcia-Garcia (1) , Alexandre Zagdoun (2) , Christophe Copéret (3) , Anne Lesage (2) , Urbano Diaz (1) , Avelino Corma (1)

1 ITQ - Instituto de Tecnología Química
2 ISA - Centre de RMN à très hauts champs
3 Laboratory of Inorganic Chemistry

A chiral mesoporous organosilica material incorporating a urea based-cinchona derivative and propylamine groups was prepared by a co-condensation method. The multisite solid catalyst efficiently promoted the asymmetric multicomponent reaction of aldehydes, malonates and nitromethane

Mots clés: ORGANOCATALYTIC MICHAEL ADDITION; CINCHONA ALKALOID DERIVATIVES; 3-DICARBONYL COMPOUNDS; MESOPOROUS ORGANOSILICA; MAGNETIC NANOPARTICLES; NITROALKENES; ALDEHYDES; MALONATE; POLYMER; ALDOL

Domaines: Chimie analytique

Pilar Garcia-Garcia, Alexandre Zagdoun, Christophe Copéret, Anne Lesage, Urbano Diaz, et al.. In Situ Preparation of a Multifunctional Chiral Hybrid Organic-Inorganic Catalyst for Asymmetric Multicomponent Reactions. Chemical Science, 2013, 4 (5), pp.2006-2012. ⟨10.1039/c3sc22310h⟩. ⟨hal-00977717⟩