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Cloud point extraction of Δ9-tetrahydrocannabinol from cannabis resin

Abstract : A cloud point extraction coupled with high performance liquid chromatography (HPLC/UV) method was developed for the determination of Δ9-tetrahydrocannabinol (THC) in micellar phase. The nonionic surfactant "Dowfax 20B102" was used to extract and pre-concentrate THC from cannabis resin, prior to its determination with a HPLC-UV system (diode array detector) with isocratic elution. The parameters and variables affecting the extraction were investigated. Under optimum conditions (1 wt.% Dowfax 20B102, 1 wt.% Na2SO4, T=318 K, t=30 min), this method yielded a quite satisfactory recovery rate (~81%). The limit of detection was 0.04 μgmL−1, and the relative standard deviation was less than 2 %. Compared with conventional solid-liquid extraction, this new method avoids the use of volatile organic solvents, therefore is environmentally safer.
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S. Ameur, Boumediene Haddou, Zoubir Derriche, Jean-Paul Canselier, Christophe Gourdon. Cloud point extraction of Δ9-tetrahydrocannabinol from cannabis resin. Analytical and Bioanalytical Chemistry, Springer Verlag, 2013, vol. 405, pp. 3117-3123. ⟨10.1007/s00216-013-6743-2⟩. ⟨hal-00976845⟩

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