Cascade Reactions in Multicompartmentalized Polymersomes

Abstract : Enzyme-filled polystyrene-b-poly(3-(isocyano-L-alanyl-aminoethyl)thiophene) (PS-b-PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor-dependent three-enzyme cascade reaction is performed, using either compatible or incompatible enzymes, which takes place across multiple compartments.
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Submitted on : Friday, March 14, 2014 - 6:27:23 PM
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Ruud J. R. W. Peters, Maïté Marguet, Sébastien Marais, Marco W. Fraaije, Jan C. M. van Hest, et al.. Cascade Reactions in Multicompartmentalized Polymersomes. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2014, 53 (1), pp.146-150. ⟨10.1002/anie.201308141⟩. ⟨hal-00959617⟩



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