pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)

Abstract : Hydrogels and nanogels made from partially hydrolyzed poly(2-ethyl-2-oxazoline) (PEtOx) were prepared by two different processes. First, both hydrogels and nanogels were made in dilute media in the presence of 1,6-hexanediol di-glycidyl ether (1) as the cross-linker. Alternatively, the PEtOx precursor was engineered into nanogels by an inverse w/o emulsion process. In the latter case, in addition to cross-linker 1,a cleavable cross-linker homologue (2), namely 1,6-hydroxyethyl disulfide-bis-di-glycidyl ether, was used to produce cleavable nanogels. The pH-responsiveness of all cross-linked PEtOx derivatives was demonstrated in an acidic environment, owing to the protonation of residual ethylene imine groups and/or tertiary amines formed during the cross-linking reaction. Nanogels derived from cross-linker 2 could readily be cleaved under a reducing environment, due to the presence of disulfide linkages at the cross-linking points.
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Camille Legros, Marie-Claire de Pauw-Gillet, Kam Chiu Tam, Sébastien Lecommandoux, Daniel Taton. pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline). Polymer Chemistry, Royal Society of Chemistry - RSC, 2013, 4 (17), pp.4801-4808. ⟨10.1039/c3py00685a⟩. ⟨hal-00959609⟩



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