Assessing the Dual Activity of a Chalcone-Phthalcyanine Conjugate: Design, Synthesis, and Antivascular and photodynamic Properties.

Abstract : Photodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.
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Journal articles
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https://hal.archives-ouvertes.fr/hal-00948878
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Submitted on : Tuesday, February 18, 2014 - 4:44:49 PM
Last modification on : Thursday, January 11, 2018 - 6:23:45 AM

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  • HAL Id : hal-00948878, version 1

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Sinem Tuncel, Aurélien Trivella, Devrim Atilla, Khalil Bennis, Huguette Savoie, et al.. Assessing the Dual Activity of a Chalcone-Phthalcyanine Conjugate: Design, Synthesis, and Antivascular and photodynamic Properties.. Molecular Pharmaceutics, American Chemical Society, 2013, 10, pp.3706-3716. ⟨hal-00948878⟩

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