ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (ST8SIA1) - Archive ouverte HAL Accéder directement au contenu
Chapitre D'ouvrage Année : 2013

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (ST8SIA1)

Résumé

The CMP-sialic acid: sialylα2-3Galβ1-4Glcβ1-O-Cer α2,8-sialyltransferase (ST8Sia I) is the key enzyme for the biosynthesis of b-series gangliosides. ST8Sia I catalyses the transfer of a sialic acid residue from CMP-sialic acid onto GM3 (Neu5Acα2-3Galβ1-4Glcβ1-O-Cer) to form GD3 (Neu5Acα2-8Neu5Acα2-3Galβ1-4Glcβ1-O-Cer). The product GD3 can be converted in GT3, and both compounds can be elongated by other monosaccharides (i.e. GalNAc, Gal and sialic acid) to form the b- and c-series gangliosides. Gangliosides from b- and c-series are essentially found in developing tissues during embryogenesis, and mainly restricted to the nervous system in healthy adults. They are enriched in glycolipid-enriched microdomains where they play a key role in the modulation of signal transduction. Moreover, substantial evidences have demonstrated the implication of ST8Sia I and b- and c-series gangliosides in oncogenesis by mediating cell proliferation, migration, tumor growth and angiogenesis.
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Dates et versions

hal-00944778 , version 1 (11-02-2014)

Identifiants

Citer

Philippe Delannoy, Marie Bobowski, Anne Harduin-Lepers. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (ST8SIA1). Naoyuki Taniguchi, Koichi Honke, Minoru Fukuda, Hisashi Narimatsu, Yoshiki Yamaguchi, Takashi Angata. Handbook of Glycosyltransferases and Related Genes, Springer-Verlag Berlin Heidelberg, pp.1-11, 2013, ⟨10.1007/SpringerReference_332175⟩. ⟨hal-00944778⟩

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