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From cerebral blood flow modeling to vascular units map in primate cortex

Abstract : The amazing topological and geometrical complexity of micro-vascular networks in the brain, and in other organs, has challenged many researchers for decades. Since the brain's vascular system is structured by a highly reticulated pial surface network which plunges down into a set of penetrating vessels, it is tempting to attribute a vascular unit to each penetrating arteriole. Recent experimental analysis have led to a breakthrough on the properties of the blood supply in the brain. Penetrating arterioles have been identified as the bottleneck of brain perfusion. Furthermore, it has also been realized that targeted clots of penetrating arterioles are not compensated by active changes in the diameter of their neighbor arteries. This observation suggests passive compensatory mechanisms resulting from the couplings between arteriolar territories consistent with other recent observations of active blood flow reorganization via collateral vessels (inter-arterial connections). A systematic investigation of the three-dimensional extent of compensation is not possible with experimental measurements but in silico simulations permit a systematic investigation of the spatial distribution of the brain perfusion.
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  • HAL Id : hal-00944750, version 1
  • OATAO : 10542

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Romain Guibert, Caroline Fonta, Franck Plouraboué. From cerebral blood flow modeling to vascular units map in primate cortex. EUROMECH Colloquium 521 - Biomedical Flows at Low Reynolds Numbers, Aug 2011, Zurich, Switzerland. ⟨hal-00944750⟩

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