Hyperpolarization of Deuterated Metabolites via Remote Cross-Polarization and Dissolution Dynamic Nuclear Polarization.

Basile Vuichoud , Jonas Milani , Aurélien Bornet , Roberto Melzi , Sami Jannin (1) , Geoffrey Bodenhausen (2)

1 ISIC - Institut des sciences et d'ingénierie chimiques
2 UPMC - Université Pierre et Marie Curie - Paris 6

: In deuterated molecules such as [1-13C]pyruvate-d3, the nuclear spin polarization of 13C nuclei can be enhanced by combining Hartmann-Hahn Cross Polarization (CP) at low temperatures (1.2 K) with Dissolution Dynamic Nuclear Polarization (D-DNP). The polarization is transferred from remote solvent protons to the 13C spins of interest. This allows one not only to slightly reduce build-up times but also to increase polarization levels and extend the lifetimes T1(13C) of the enhanced 13C polarization during and after transfer from the polarizer to the NMR or MRI system. This extends timescales over which metabolic processes and chemical reactions can be monitored.

Domaines: Chimie organique

Basile Vuichoud, Jonas Milani, Aurélien Bornet, Roberto Melzi, Sami Jannin, et al.. Hyperpolarization of Deuterated Metabolites via Remote Cross-Polarization and Dissolution Dynamic Nuclear Polarization.. Journal of Physical Chemistry B, 2014, 118 (5), pp.1411-1415. ⟨10.1021/jp4118776⟩. ⟨hal-00926687⟩