Laryngeal two-phase flow in realistic breathing conditions
Résumé
Liquid aerosols are efficient vectors for drug delivery in upper and lower respiratory tract. Characteristics of inhaled particles, flow properties, and airway morphology represent the main influential factors of the transport mechanisms. Numerous works have been carried out to characterize the airflow behaviour during human breathing [Baier, 1977; Brancatisano, 1983], and to determine the trajectories of inhaled particles through the extrathoracic region. Recent studies [Brouns, 2007] have shown the relevance of the laryngeal geometry and, more precisely, the impact of glottal aperture on fluid dynamics and aerosol deposition mechanics. In this study we focus on two main objectives: i) determine the glottal dynamics during two breathing conditions (eupnea and tachypnea); ii) predict the influence of both carrier gas and aerosols' properties on the unsteady laryngeal flow and the aerosol deposition, using CFD simulations in a simplified 3D glottis model during these two breathing conditions.
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