Implementation and validation of the thermogravimetric method for the determination of equilibrium vapour pressure values and sublimation enthalpies of frozen organic formulations used in drug freeze-drying processes

Abstract : he modelling of the sublimation step needs the knowledge of basic thermodynamic properties as the equilibrium solid-vapour pressures and the sublimation enthalpies. Unfortunately these thermodynamic properties are generally missing in the literature. Tert-butanol (TBA) co-solvent has been used largely as solvent in freeze-drying formulation. Thus, in the present study, we have determined the equilibrium values of vapour pressures (solid-vapour and liquid-vapour equilibrium) and sublimation enthalpies of pure TBA and for its eutectic mixture with water, namely the 90% (w/w) TBA + 10% (w/w) mixture, by using two different and comparative methods: the Thermogravimetric Method crc Method) and the Static Method. TG experiments were conducted in dynamic conditions in a temperature range from -30 degrees C to 80 degrees C. Both methods led to similar values with a relative deviation less than 2%. This validation proved that the TG method is a rapid, reliable and precise technique for the determination of solid/vapour and liquid/vapour equilibrium pressures for pure substances or for co-solvent + water mixtures at eutectic/azeotropic compositions.
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Chemical Engineering Research and Design, Elsevier, 2011, 89 (12A), pp.2606-2612. 〈10.1016/j.cherd.2011.05.004〉
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Soumis le : mardi 29 octobre 2013 - 11:45:19
Dernière modification le : jeudi 19 avril 2018 - 14:34:08

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Eni Bogdani, Rim Daoussi, Séverine Vessot, Jacques Jose, Julien Andrieu. Implementation and validation of the thermogravimetric method for the determination of equilibrium vapour pressure values and sublimation enthalpies of frozen organic formulations used in drug freeze-drying processes. Chemical Engineering Research and Design, Elsevier, 2011, 89 (12A), pp.2606-2612. 〈10.1016/j.cherd.2011.05.004〉. 〈hal-00877854〉

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