Mucoadhesion evaluation of polysaccharide gels for vaginal application by using rheological and indentation measurements

Abstract : The influence of hyaluronic acid (HA) and fructooligosaccharides (FOS) addition on low methyl pectin (LMP) gelation has been investigated in order to produce adhesive gel-based microparticles suitable for the development of a vaginal delivery system of pro- and prebiotics. First, dynamic rheological measurements were performed on LMP/Ca2+ gels with or without FOS and HA in presence or not of porcine stomach mucins. This rheological method is known to translate the interactions between polymer and mucins and then simulate the polymer bioadhesion potential. Nevertheless, as this method is disputed, in vitro and ex vivo indentation test measurements were also achieved in order to correlate the results obtained. Despite some different results, the overall tendency indicates that addition of HA and FOS enhanced the mucoadhesive properties of LMP gels. Moreover, gel-based microparticles obtained according to an emulsification/gelation method and composed by LMP 3% (w/v), FOS 5% (w/v) and HA 0.5% (w/v) displayed a mucoadhesive potential adapted to vaginal delivery system.
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Colloids and Surfaces B: Biointerfaces, Elsevier, 2012, 92, pp.168-174. 〈10.1016/j.colsurfb.2011.11.039〉
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https://hal.archives-ouvertes.fr/hal-00877405
Contributeur : Agnès Bussy <>
Soumis le : lundi 28 octobre 2013 - 14:19:08
Dernière modification le : mardi 11 décembre 2018 - 11:22:05

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Dorothée Pliszczak, Claire Bordes, Sandrine Bourgeois, Pédro Marotte, Hassan Zahouani, et al.. Mucoadhesion evaluation of polysaccharide gels for vaginal application by using rheological and indentation measurements. Colloids and Surfaces B: Biointerfaces, Elsevier, 2012, 92, pp.168-174. 〈10.1016/j.colsurfb.2011.11.039〉. 〈hal-00877405〉

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