 |
Journal articles
Photochemical behaviour of propranolol in environmental waters: the hydroxylated photoproducts
Abstract : The UV irradiation of propranolol, one of the beta-blockers currently used in cardiac medicine, was studied. During irradiation, the samples were analysed by LC/MS/MS, using a Waters Symmetry C-18 (3.5 mu m 150 x 2.1 mm) column. The main photoproducts were identified from mono-, di- and tri-hydroxylation of the propranolol naphthalenic skeleton. Hydroxyl group positions were predicted by means of theoretical calculations. Partial charge calculations of the propranolol atoms predicted the formation of four mono-hydroxylated compounds, two of them being the most probable. From these two compounds, three di-hydroxylated compounds were predicted. Then the calculations from the two most probable di-hydroxylated compounds were used to propose three tri-hydroxylated propranolol compounds. It was found that the same hydroxylated photoproducts are formed in pure water and in treatment plant waste water.
https://hal.archives-ouvertes.fr/hal-00876038
Contributor : Agnès Bussy <>
Submitted on : Wednesday, October 23, 2013 - 3:19:20 PM
Last modification on : Monday, April 20, 2020 - 9:46:03 AM
Contributor : Agnès Bussy <>
Submitted on : Wednesday, October 23, 2013 - 3:19:20 PM
Last modification on : Monday, April 20, 2020 - 9:46:03 AM
