Photochemical behaviour of propranolol in environmental waters: the hydroxylated photoproducts

Abstract : The UV irradiation of propranolol, one of the beta-blockers currently used in cardiac medicine, was studied. During irradiation, the samples were analysed by LC/MS/MS, using a Waters Symmetry C-18 (3.5 mu m 150 x 2.1 mm) column. The main photoproducts were identified from mono-, di- and tri-hydroxylation of the propranolol naphthalenic skeleton. Hydroxyl group positions were predicted by means of theoretical calculations. Partial charge calculations of the propranolol atoms predicted the formation of four mono-hydroxylated compounds, two of them being the most probable. From these two compounds, three di-hydroxylated compounds were predicted. Then the calculations from the two most probable di-hydroxylated compounds were used to propose three tri-hydroxylated propranolol compounds. It was found that the same hydroxylated photoproducts are formed in pure water and in treatment plant waste water.
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Submitted on : Wednesday, October 23, 2013 - 3:19:20 PM
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Anne Piram, René Faure, Henry Chermette, Claire Bordes, Bernard Herbreteau, et al.. Photochemical behaviour of propranolol in environmental waters: the hydroxylated photoproducts. International Journal of Environmental Analytical Chemistry, Taylor & Francis, 2012, 92 (1), pp.96-109. ⟨10.1080/03067319.2010.497920⟩. ⟨hal-00876038⟩

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