HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

The Arabidopsis peptide kiss of death is an inducer of programmed cell death

Abstract : Programmed cell death (PCD) has a key role in defence and development of all multicellular organisms. In plants, there is a large gap in our knowledge of the molecular machinery involved at the various stages of PCD, especially the early steps. Here, we identify kiss of death (KOD) encoding a 25-amino-acid peptide that activates a PCD pathway in Arabidopsis thaliana. Two mutant alleles of KOD exhibited a reduced PCD of the suspensor, a single file of cells that support embryo development, and a reduced PCD of root hairs after a 55 degrees C heat shock. KOD expression was found to be inducible by biotic and abiotic stresses. Furthermore, KOD expression was sufficient to cause death in leaves or seedlings and to activate caspase-like activities. In addition, KOD-induced PCD required light in leaves and was repressed by the PCD-suppressor genes AtBax inhibitor 1 and p35. KOD expression resulted in depolarization of the mitochondrial membrane, placing KOD above mitochondria dysfunction, an early step in plant PCD. A KOD::GFP fusion, however, localized in the cytosol of cells and not mitochondria
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-00873858
Contributor : Agnès Bussy Connect in order to contact the contributor
Submitted on : Wednesday, October 16, 2013 - 3:39:55 PM
Last modification on : Thursday, January 13, 2022 - 2:20:44 PM

Links full text

Identifiers

Collections

Citation

Robert Blanvillain, Bennett Young, Yao-Min Cai, Valérie Hecht, Fabrice Varoquaux, et al.. The Arabidopsis peptide kiss of death is an inducer of programmed cell death. EMBO Journal, EMBO Press, 2011, 30 (6), pp.1173-1183. ⟨10.1038/emboj.2011.14⟩. ⟨hal-00873858⟩

Share

Metrics

Record views

150