The CD95 signaling pathway: To not die and fly.

Aubin Penna (1) , Nadine Khadra (1) , Sébastien Tauzin (1) , Pierre Vacher (2) , Patrick Legembre (1)

1 Récepteur de mort et échappement tumoral
2 VINCO - Validation et identification de nouvelles cibles en oncologie

Our recent findings indicate that cells exposed to transmembrane (m-CD95L) or metalloprotease-cleaved CD95L (cl-CD95L) undergo a localized Ca(2+)entry that not only inhibits the initial steps of the CD95-mediated apoptotic signal but also promotes cell motility. Based on recent findings published on the non-apoptotic signals induced by CD95, we discuss how m-CD95L and cl-CD95L diverging by their stoichiometry could both contribute to the immune response by first recruiting activated T lymphocytes in the inflamed area and later by eliminating infected and transformed cells.

Mots clés: Apoptosis; calcium; Fas; FasL; lymphocyte; migration; Orai1; PI3K; TNF

Domaines: Biologie cellulaire; Cancer

Aubin Penna, Nadine Khadra, Sébastien Tauzin, Pierre Vacher, Patrick Legembre. The CD95 signaling pathway: To not die and fly.. Communicative and Integrative Biology, 2012, 5 (2), pp.190-2. ⟨10.4161/cib.18888⟩. ⟨hal-00873761⟩