D. J. Selkoe and D. Schenk, Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics, Annu Rev Pharmacol Toxicol, vol.43, p.12415125, 2003.

C. Duyckaerts, B. Delatour, and M. C. Potier, Classification and basic pathology of Alzheimer disease, Acta Neuropathol, vol.118, pp.5-36, 2009.

K. H. Ashe, Learning and memory in transgenic mice modeling Alzheimer's disease, Learn Mem, vol.8, p.11773429, 2001.

J. L. Eriksen and C. G. Janus, Plaques, tangles, and memory loss in mouse models of neurodegeneration, Behav Genet, vol.37, p.17072762, 2007.

T. L. Spires and B. T. Hyman, Transgenic models of Alzheimer's disease: learning from animals, NeuroRx, vol.2, p.16389306, 2005.

R. Kimura and M. Ohno, Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model, Neurobiol Dis, vol.33, p.19026746, 2009.

H. Oakley, S. L. Cole, S. Logan, E. Maus, and P. Shao, Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation, J Neurosci, vol.26, p.17021169, 2006.

M. Ohno, Genetic and pharmacological basis for therapeutic inhibition of beta-and gamma-secretases in mouse models of Alzheimer's memory deficits, Rev Neurosci, vol.17, p.17139843, 2006.

J. Hongpaisan, M. K. Sun, and D. L. Alkon, PKC epsilon activation prevents synaptic loss, Abeta elevation, 2011.

, Alzheimer's disease transgenic mice, J Neurosci, vol.31, p.21228172

L. Devi and M. Ohno, Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD, 2010.

, Alzheimer's disease model mice, Eur J Neurosci, vol.31, pp.110-118, 20092558.

S. D. Girard, K. Baranger, C. Gauthier, M. Jacquet, and A. Bernard, Evidence for Early Cognitive Impairment Related to Frontal Cortex in the 5XFAD Mouse Model of Alzheimer's Disease, J Alzheimers Dis, vol.33, p.23042214, 2012.

S. Jawhar, A. Trawicka, C. Jenneckens, T. A. Bayer, and O. Wirths, Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Abeta aggregation in the 5XFAD mouse model of Alzheimer's disease, Neurobiol Aging, vol.33, pp.129-140, 2012.

M. Ohno, Failures to reconsolidate memory in a mouse model of Alzheimer's disease, Neurobiol Learn Mem, vol.92, p.19435612, 2009.

E. Mcgowan, J. Eriksen, and M. Hutton, A decade of modeling Alzheimer's disease in transgenic mice, Trends Genet, vol.22, p.16567017, 2006.

M. A. Lynch, Long-term potentiation and memory, Physiol Rev, vol.84, p.14715912, 2004.

Y. Dudai, The neurobiology of consolidations, or, how stable is the engram?, Annu Rev Psychol, vol.55, p.14744210, 2004.

P. W. Frankland and B. Bontempi, The organization of recent and remote memories, Nat Rev Neurosci, vol.6, p.15685217, 2005.

J. L. Mcclelland, B. L. Mcnaughton, O. Reilly, and R. C. , Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory, Psychol Rev, vol.102, p.7624455, 1995.

L. R. Squire and P. J. Bayley, The neuroscience of remote memory, Curr Opin Neurobiol, vol.17, p.17336513, 2007.

J. Götz and L. M. Ittner, Animal models of Alzheimer's disease and frontotemporal dementia, Nat Rev Neurosci, vol.9, p.18568014, 2008.

G. A. Carlesimo and M. Oscar-berman, Memory deficits in Alzheimer's patients: a comprehensive review, Neuropsychol Rev, vol.3, p.1300219, 1992.
DOI : 10.1007/bf01108841

J. Hom, General and specific cognitive dysfunctions in patients with Alzheimer's disease, Arch Clin Neuropsychol, vol.7, p.14589636, 1992.
DOI : 10.1093/arclin/7.2.121

B. Achour, S. Pascual, and O. , Glia: the many ways to modulate synaptic plasticity, Neurochem Int, vol.57, pp.440-445, 2010.

F. Lanté, N. Crouzin, and M. Vignes, Unveiling novel forms of hippocampal synaptic plasticity with microelectrode arrays, J Integr Neurosci, vol.7, p.18763723, 2008.

M. O. Heuschkel, M. Fejtl, M. Raggenbass, D. Bertrand, and P. Renaud, A three-dimensional multi-electrode array for multi-site stimulation and recording in acute brain slices, J Neurosci Methods, vol.114, p.11856564, 2002.
DOI : 10.1016/s0165-0270(01)00514-3

M. V. Kopanitsa, N. O. Afinowi, and S. G. Grant, Recording long-term potentiation of synaptic transmission by three-dimensional multielectrode arrays, BMC Neurosci, vol.7, p.61, 2006.

R. S. Zucker and W. G. Regehr, Short-term synaptic plasticity, Annu Rev Physiol, vol.64, p.11826273, 2002.

R. Gerlai, Hippocampal LTP and memory in mouse strains: is there evidence for a causal relationship, Hippocampus, vol.12, p.12440580, 2002.

P. V. Nguyen, Comparative plasticity of brain synapses in inbred mouse strains, J Exp Biol, vol.209, p.16731805, 2006.
DOI : 10.1242/jeb.01985

URL : http://jeb.biologists.org/content/209/12/2293.full.pdf

P. V. Nguyen, T. Abel, E. R. Kandel, and R. Bourtchouladze, Straindependent differences in LTP and hippocampus-dependent memory in inbred mice, Learn Mem, vol.7, p.10837506, 2000.
DOI : 10.1101/lm.7.3.170

URL : http://learnmem.cshlp.org/content/7/3/170.full.pdf

H. Braak and E. Braak, Neuropathological staging of Alzheimerrelated changes, Acta Neuropathol, vol.82, p.1759558, 1991.

A. Bozzao, R. Floris, M. E. Baviera, A. Apruzzese, and G. Simonetti, Diffusion and perfusion MR imaging in cases of Alzheimer's disease: correlations with cortical atrophy and lesion load, AJNR Am J Neuroradiol, vol.22, p.11415893, 2001.

J. M. Stephen, R. Montaño, C. H. Donahue, J. C. Adair, and J. Knoefel, Somatosensory responses in normal aging, mild cognitive impairment, and Alzheimer's disease, J Neural Transm, vol.117, pp.217-225, 2010.

C. Marchetti and H. Marie, Hippocampal synaptic plasticity in Alzheimer's disease: what have we learned so far from transgenic models?, Rev Neurosci, vol.22, p.21732714, 2011.
DOI : 10.1016/j.jalz.2011.05.1463

F. Battaglia, H. Y. Wang, M. F. Ghilardi, E. Gashi, and A. Quartarone, Cortical plasticity in Alzheimer's disease in humans and rodents, Biol Psychiatry, vol.62, p.17651702, 2007.
DOI : 10.1016/j.biopsych.2007.02.027

R. Kimura, L. Devi, and M. Ohno, Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice, J Neurochem, vol.113, pp.248-261, 2010.

P. F. Chapman, G. L. White, M. W. Jones, D. Cooper-blacketer, and M. Vj, Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice, Nat Neurosci, vol.2, p.10195221, 1999.

S. M. Fitzjohn, R. A. Morton, F. Kuenzi, T. W. Rosahl, and M. Shearman, Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein, J Neurosci, vol.21, p.11425896, 2001.

J. J. Palop, J. Chin, E. D. Roberson, J. Wang, and M. T. Thwin, Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease, Neuron, vol.55, p.17785178, 2007.

G. Buzsáki, Theta oscillations in the hippocampus, Neuron, vol.33, pp.325-340, 2002.

M. A. Castro-alamancos and B. W. Connors, Short-term synaptic enhancement and long-term potentiation in neocortex, Proc Natl Acad Sci U S A, vol.93, p.8577765, 1996.

R. V. Hernandez, M. M. Navarro, W. A. Rodriguez, J. L. Martinez, and R. G. Lebaron, Differences in the magnitude of long-term potentiation produced by theta burst and high frequency stimulation protocols matched in stimulus number, Brain Res Protoc, vol.15, pp.6-13, 2005.

N. K. Gonatas, W. Anderson, and I. Evangelista, The contribution of altered synapses in the senile plaque: an electron microscopic study in Alzheimer's dementia, J Neuropathol Exp Neurol, vol.26, p.6022163, 1967.

B. Delatour, V. Blanchard, L. Pradier, and C. Duyckaerts, Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model, Neurobiol Dis, vol.16, p.15207260, 2004.

P. K. Chang, D. Verbich, and R. A. Mckinney, AMPA receptors as drug targets in neurological disease-advantages, caveats, and future outlook, Eur J Neurosci, vol.35, p.22708602, 2012.

M. A. Johnson and P. J. Lombroso, A common STEP in the synaptic pathology of diverse neuropsychiatric disorders, Yale J Biol Med, vol.85, p.23239949, 2012.

T. Ondrejcak, I. Klyubin, N. W. Hu, A. E. Barry, and W. K. Cullen, Alzheimer's disease amyloid beta-protein and synaptic function, Neuromol Med, vol.12, pp.13-26, 2010.

M. M. Esiri and S. A. Chance, Vulnerability to Alzheimer's pathology in neocortex: the roles of plasticity and columnar organization, J Alzheimers Dis, vol.9, p.16914847, 2006.

V. E. Koliatsos, A. Kecojevic, J. C. Troncoso, M. C. Gastard, and D. A. Bennett, Early involvement of small inhibitory cortical interneurons in Alzheimer's disease, Acta Neuropathol, vol.112, p.16758165, 2006.

G. León-espinosa, J. Defelipe, and A. Muñoz, Effects of amyloid-beta plaque proximity on the axon initial segment of pyramidal cells, J Alzheimers Dis, vol.29, p.22337828, 2012.

B. Ramos, D. Baglietto-vargas, J. C. Del-rio, I. Moreno-gonzalez, and C. Santamaria, Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease, Neurobiol Aging, vol.27, p.16271420, 2006.

L. Verret, E. O. Mann, G. B. Hang, A. M. Barth, and I. Cobos, Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model, Cell, vol.149, p.22541439, 2012.

K. F. Bell, C. Cuello, and A. , Altered synaptic function in Alzheimer's disease, Eur J Pharmacol, vol.545, p.16887118, 2006.

K. F. Bell, A. Ducatenzeiler, A. Ribeiro-da-silva, K. Duff, and D. A. Bennett, The amyloid pathology progresses in a neurotransmitter-specific manner, Neurobiol Aging, vol.27, p.16271419, 2006.