Gold-mediated synthesis and functionalization of chiral halopyridones.

Khanh Hung Nguyen (1) , Sophie Tomasi (1) , Myriam Le Roch (1) , Loïc Toupet (2) , Jacques Renault (1) , Philippe Uriac (1) , Nicolas Gouault (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 IPR - Institut de Physique de Rennes

A rapid and efficient one-step halopyridone synthesis has been developed based on gold-catalyzed cyclization of β-amino-ynone intermediates and halodeauration process.

Domaines: Chimie organique

Khanh Hung Nguyen, Sophie Tomasi, Myriam Le Roch, Loïc Toupet, Jacques Renault, et al.. Gold-mediated synthesis and functionalization of chiral halopyridones.. Journal of Organic Chemistry, 2013, 78 (16), pp.7809-15. ⟨10.1021/jo400827b⟩. ⟨hal-00866844⟩