Enantioselective Organocatalyzed Domino Synthesis of Six-Membered Carbocycles

Sébastien Goudedranche (1) , Wilfried Raimondi (2) , Xavier Bugaut (2) , Thierry Constantieux (2) , Damien Bonne (2) , Jean Rodriguez (2)

1 ISM2 - Institut des Sciences Moléculaires de Marseille
2 STeRéO

Polysubstituted chiral cyclohexanes and cyclohexenes are important building blocks in organic synthesis. From historical and pioneering reports to the most recent accounts, this review focuses on domino enantioselective organocatalytic methodologies that have allowed the control of the relative and absolute configurations of up to six stereogenic centers in the construction of these versatile molecular architectures.

Mots clés: organocatalysis; domino reactions; multicomponent reactions; cyclohexanes; cyclohexenes; asymmetric synthesis

Domaines: Chimie organique

Sébastien Goudedranche, Wilfried Raimondi, Xavier Bugaut, Thierry Constantieux, Damien Bonne, et al.. Enantioselective Organocatalyzed Domino Synthesis of Six-Membered Carbocycles. Synthesis: Journal of Synthetic Organic Chemistry, 2013, 45, pp.1909-1930. ⟨10.1055/s-0033-1338484⟩. ⟨hal-00861699⟩