Modélisation numérique et simulation : nouvelles applications en pharmacologie [New approaches in pharmacology: numerical modelling and simulation]

Jean-Pierre Boissel 1 Michel Cucherat 1 Patrice Nony 1 Marie-Aimée Dronne 1, 2, * Behrouz Kassaï 1, 3 Sylvie Chabaud 4
* Corresponding author
1 Evaluation et modélisation des effets thérapeutiques
Département biostatistiques et modélisation pour la santé et l'environnement [LBBE]
2 NUMED - Numerical Medicine
UMPA-ENSL - Unité de Mathématiques Pures et Appliquées, Inria Grenoble - Rhône-Alpes
Abstract : The complexity of pathophysiological mechanisms is beyond the capabilities of traditional approaches. Many of the decision-making problems in public health, such as initiating mass screening, are complex. Progress in genomics and proteomics, and the resulting extraordinary increase in knowledge with regard to interactions between gene expression, the environment and behaviour, the customisation of risk factors and the need to combine therapies that individually have minimal though well documented efficacy, has led doctors to raise new questions: how to optimise choice and the application of therapeutic strategies at the individual rather than the group level, while taking into account all the available evidence? This is essentially a problem of complexity with dimensions similar to the previous ones: multiple parameters with nonlinear relationships between them, varying time scales that cannot be ignored etc. Numerical modelling and simulation (in silico investigations) have the potential to meet these challenges. Such approaches are considered in drug innovation and development. They require a multidisciplinary approach, and this will involve modification of the way research in pharmacology is conducted.
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Contributor : Marie-Aimée Dronne <>
Submitted on : Friday, September 6, 2013 - 11:18:27 PM
Last modification on : Tuesday, November 19, 2019 - 2:43:58 AM

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Jean-Pierre Boissel, Michel Cucherat, Patrice Nony, Marie-Aimée Dronne, Behrouz Kassaï, et al.. Modélisation numérique et simulation : nouvelles applications en pharmacologie [New approaches in pharmacology: numerical modelling and simulation]. Thérapie, EDP Sciences, 2005, 60 (1), pp.1-15. ⟨hal-00859350⟩

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