U. Zweifel and A. Hagstrom, Total Counts of Marine Bacteria Include a Large Fraction of Non-Nucleoid-Containing Bacteria (Ghosts), Appl Environ Microbiol, vol.61, pp.2180-2185, 1995.

C. Suttle, Viruses in the sea, Nature, vol.155, issue.7057, pp.356-361, 2005.
DOI : 10.1006/viro.2001.1028

A. Otero-gonzález, B. Magalhães, M. Garcia-villarino, C. López-abarrategui, D. Sousa et al., Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection control, The FASEB Journal, vol.24, issue.5, pp.1320-1334, 2010.
DOI : 10.1096/fj.09-143388

N. Afacan, A. Yeung, O. Pena, and R. Hancock, Therapeutic Potential of Host Defense Peptides in Antibiotic-resistant Infections, Current Pharmaceutical Design, vol.18, issue.6, pp.807-819, 2012.
DOI : 10.2174/138161212799277617

T. Nakatsuji and R. Gallo, Antimicrobial Peptides: Old Molecules with New Ideas, Journal of Investigative Dermatology, vol.132, issue.3, pp.887-895, 2012.
DOI : 10.1038/jid.2011.387

M. Pasupuleti, A. Schmidtchen, and M. Malmsten, Antimicrobial peptides: key components of the innate immune system, Critical Reviews in Biotechnology, vol.15, issue.1, pp.143-171, 2011.
DOI : 10.4161/viru.1.5.12983

S. Sperstad, T. Haug, H. Blencke, O. Styrvold, C. Li et al., Antimicrobial peptides from marine invertebrates: Challenges and perspectives in marine antimicrobial peptide discovery, Biotechnology Advances, vol.29, issue.5, pp.519-530, 2011.
DOI : 10.1016/j.biotechadv.2011.05.021

G. Wang, X. Li, and Z. Wang, APD2: the updated antimicrobial peptide database and its application in peptide design, Nucleic Acids Research, vol.37, issue.Database, pp.933-937, 2009.
DOI : 10.1093/nar/gkn823

S. Thomas, S. Karnik, R. Barai, V. Jayaraman, and S. Idicula-thomas, CAMP: a useful resource for research on antimicrobial peptides, Nucleic Acids Research, vol.38, issue.Database, pp.774-780, 2010.
DOI : 10.1093/nar/gkp1021

V. Seshadri-sundararajan, M. Gabere, A. Pretorius, S. Adam, A. Christoffels et al., DAMPD: a manually curated antimicrobial peptide database, Nucleic Acids Research, vol.40, issue.D1, 2011.
DOI : 10.1093/nar/gkr1063

S. Seebah, A. Suresh, S. Zhuo, Y. Choong, H. Chua et al., Defensins knowledgebase: a manually curated database and information source focused on the defensins family of antimicrobial peptides, Nucleic Acids Research, vol.35, issue.Database, pp.265-268, 2007.
DOI : 10.1093/nar/gkl866

R. Hammami, A. Zouhir, L. Lay, C. , B. Hamida et al., BACTIBASE second release: a database and tool platform for bacteriocin characterization, BMC Microbiology, vol.10, issue.1, pp.22-32, 2010.
DOI : 10.1186/1471-2180-10-22

J. Tincu and S. Taylor, Antimicrobial Peptides from Marine Invertebrates, Antimicrobial Agents and Chemotherapy, vol.48, issue.10, pp.3645-3654, 2004.
DOI : 10.1128/AAC.48.10.3645-3654.2004

V. Rajanbabu and J. Chen, Applications of antimicrobial peptides from fish and perspectives for the future, Peptides, vol.32, issue.2, pp.415-420, 2011.
DOI : 10.1016/j.peptides.2010.11.005

F. Hubert, T. Noël, and P. Roch, ), European Journal of Biochemistry, vol.265, issue.1, pp.302-306, 1996.
DOI : 10.1111/j.1432-1033.1996.0302h.x

G. Mitta, F. Hubert, E. Dyrynda, P. Boudry, and P. Roch, Mytilin B and MGD2, two antimicrobial peptides of marine mussels: gene structure and expression analysis, Developmental & Comparative Immunology, vol.24, issue.4, pp.381-393, 2000.
DOI : 10.1016/S0145-305X(99)00084-1

G. Mitta, F. Vandenbulcke, T. Noël, B. Romestand, J. Beauvillain et al., Differential distribution and defence involvement of antimicrobial peptides in mussel, J. Cell. Sci, vol.113, pp.2759-2769, 2000.

M. Gerdol, D. Moro, G. Manfrin, C. Venier, P. Pallavicini et al., Big defensins and mytimacins, new AMP families of the Mediterranean mussel Mytilus galloprovincialis, Developmental & Comparative Immunology, vol.36, issue.2, pp.390-399, 2012.
DOI : 10.1016/j.dci.2011.08.003

G. Mitta, F. Vandenbulcke, F. Hubert, and P. Roch, Mussel defensins are synthesised and processed in granulocytes then released into the plasma after bacterial challenge, J. Cell. Sci, vol.112, pp.4233-4242, 1999.

J. Seo, J. Crawford, K. Stone, and E. Noga, Purification of a novel arthropod defensin from the American oyster, Crassostrea virginica, Biochemical and Biophysical Research Communications, vol.338, issue.4, 1998.
DOI : 10.1016/j.bbrc.2005.11.013

Y. Gueguen, A. Herpin, A. Aumelas, J. Garnier, J. Fievet et al., Characterization of a Defensin from the Oyster Crassostrea gigas: RECOMBINANT PRODUCTION, FOLDING, SOLUTION STRUCTURE, ANTIMICROBIAL ACTIVITIES, AND GENE EXPRESSION, Journal of Biological Chemistry, vol.281, issue.1, pp.313-323, 2006.
DOI : 10.1074/jbc.M510850200

URL : https://hal.archives-ouvertes.fr/hal-00286204

M. Gonzalez, Y. Gueguen, G. Desserre, D. Lorgeril, J. Romestand et al., Molecular characterization of two isoforms of defensin from hemocytes of the oyster Crassostrea gigas, Developmental & Comparative Immunology, vol.31, issue.4, pp.332-339, 2007.
DOI : 10.1016/j.dci.2006.07.006

R. Rosa, A. Santini, J. Fievet, P. Bulet, D. Destoumieux-garzón et al., Big Defensins, a Diverse Family of Antimicrobial Peptides That Follows Different Patterns of Expression in Hemocytes of the Oyster Crassostrea gigas, PLoS ONE, vol.269, issue.9, 2011.
DOI : 10.1371/journal.pone.0025594.s001

P. Schmitt, M. Wilmes, M. Pugnière, A. Aumelas, E. Bachère et al., Insight into Invertebrate Defensin Mechanism of Action, Journal of Biological Chemistry, vol.285, issue.38, pp.29208-29216, 2010.
DOI : 10.1074/jbc.M110.143388

F. Hubert, W. Van-der-knaap, T. Noël, and P. Roch, (bivalve molluscs) hemolymph, Aquatic Living Resources, vol.9, issue.2, pp.115-124, 1996.
DOI : 10.1051/alr:1996015

R. Anderson and A. Beaven, Activit??s antibact??riennes du plasma de l'hu??tre (Crassostrea virginica) et des moules (Mytilus edulis et Geukensia demissa)., Aquatic Living Resources, vol.14, issue.6, pp.343-349, 2001.
DOI : 10.1016/S0990-7440(01)01143-3

D. Defer, N. Bourgougnon, and Y. Fleury, Screening for antibacterial and antiviral activities in three bivalve and two gastropod marine molluscs, Aquaculture, vol.293, issue.1-2, 2009.
DOI : 10.1016/j.aquaculture.2009.03.047

P. Schmitt, R. Rosa, M. Duperthuy, D. Lorgeril, J. Bachère et al., The Antimicrobial Defense of the Pacific Oyster, Crassostrea gigas. How Diversity may Compensate for Scarcity in the Regulation of Resident/Pathogenic Microflora, Frontiers in Microbiology, vol.3, 2012.
DOI : 10.3389/fmicb.2012.00160

I. Wiegand, K. Hilpert, and R. Hancock, Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances, Nature Protocols, vol.217, issue.2, pp.163-175521, 2007.
DOI : 10.1038/nprot.2007.521

Y. Fleury, M. Dayem, J. Montagne, E. Chaboisseau, L. Caer et al., Covalent structure, synthesis, and structure-function studies of mesentericin Y 105(37), a defensive peptide from gram-positive bacteria Leuconostoc mesenteroides, J. Biol. Chem, vol.271, pp.14421-14429, 1996.

H. Schägger, V. Jagow, and G. , Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa, Analytical Biochemistry, vol.166, issue.2, pp.368-379, 1987.
DOI : 10.1016/0003-2697(87)90587-2

A. Bhunia and M. Johnson, A modified method to directly detect in SDS-PAGE the bacteriocin of Pediococcus acidilactici, Letters in Applied Microbiology, vol.57, issue.1, pp.5-7, 1992.
DOI : 10.1007/BF01569434

E. Stackebrandt and J. Ebers, Taxonomic parameters revisited : tarnished gold standards, pp.152-156, 2006.

F. Desriac, D. Defer, N. Bourgougnon, B. Brillet, L. Chevalier et al., Bacteriocin as Weapons in the Marine Animal-Associated Bacteria Warfare: Inventory and Potential Applications as an Aquaculture Probiotic, Marine Drugs, vol.8, issue.4, pp.1153-117710, 2010.
DOI : 10.3390/md8041153

URL : https://hal.archives-ouvertes.fr/hal-00858183

M. Yeaman and N. Yount, Mechanisms of Antimicrobial Peptide Action and Resistance, Pharmacological Reviews, vol.55, issue.1, pp.27-55, 2003.
DOI : 10.1124/pr.55.1.2

Y. Gueguen, B. Romestand, J. Fievet, P. Schmitt, D. Destoumieux-garzón et al., Oyster hemocytes express a proline-rich peptide displaying synergistic antimicrobial activity with a defensin, Molecular Immunology, vol.46, issue.4, pp.516-522, 2009.
DOI : 10.1016/j.molimm.2008.07.021

M. Gonzalez, Y. Gueguen, D. Destoumieux-garzón, B. Romestand, J. Fievet et al., Evidence of a bactericidal permeability increasing protein in an invertebrate, the Crassostrea gigas Cg-BPI, Proceedings of the National Academy of Sciences, vol.104, issue.45, pp.17759-17764, 2007.
DOI : 10.1073/pnas.0702281104

URL : https://hal.archives-ouvertes.fr/hal-00258926

P. Schmitt, J. Lorgeril, . De, Y. Gueguen, D. Destoumieux-garzón et al., Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas, Developmental & Comparative Immunology, vol.37, issue.3-4, pp.363-370, 2012.
DOI : 10.1016/j.dci.2012.01.004

D. Field, C. Hill, P. Cotter, and R. Ross, The dawning of a ???Golden era??? in lantibiotic bioengineering, Molecular Microbiology, vol.246, issue.5, pp.1077-1087, 2010.
DOI : 10.1111/j.1365-2958.2010.07406.x

G. Zhang, X. Fang, X. Guo, L. Li, R. Luo et al., The oyster genome reveals stress adaptation and complexity of shell formation, Nature, vol.10, issue.7418, pp.49-5410, 1038.
DOI : 10.1038/nature11413

Y. Gueguen, J. Cadoret, D. Flament, C. Barreau-roumiguière, A. Girardot et al., Immune gene discovery by expressed sequence tags generated from hemocytes of the bacteria-challenged oyster, Crassostrea gigas, Gene, vol.303, pp.139-145, 2003.
DOI : 10.1016/S0378-1119(02)01149-6

R. Fontana, M. Mendes, B. Souza, . De, K. Konno et al., Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera), Peptides, vol.25, issue.6, pp.919-928, 2004.
DOI : 10.1016/j.peptides.2004.03.016

S. Caboche, M. Pupin, V. Leclère, A. Fontaine, P. Jacques et al., NORINE: a database of nonribosomal peptides, Nucleic Acids Research, vol.36, issue.Database, pp.326-331, 2008.
DOI : 10.1093/nar/gkm792

URL : https://hal.archives-ouvertes.fr/inria-00281012

J. Olafsen, H. Mikkelsen, H. Giaever, H. Hansen, and G. , Indigenous Bacteria in Hemolymph and Tissues of Marine Bivalves at Low Temperatures, Appl Environ Microbiol, vol.59, pp.1848-1854, 1993.

M. Garnier, Y. Labreuche, C. Garcia, M. Robert, and J. Nicolas, Evidence for the Involvement of Pathogenic Bacteria in Summer Mortalities of the Pacific Oyster Crassostrea gigas, Microbial Ecology, vol.61, issue.1, pp.187-196, 2007.
DOI : 10.1007/s00248-006-9061-9

J. Bowman, Bioactive Compound Synthetic Capacity and Ecological Significance of Marine Bacterial Genus Pseudoalteromonas, Marine Drugs, vol.5, issue.4, pp.220-241, 2007.
DOI : 10.3390/md504220

B. Flemer, J. Kennedy, L. Margassery, J. Morrissey, O. Gara et al., Diversity and antimicrobial activities of microbes from two Irish marine sponges, Suberites carnosus and Leucosolenia sp., Journal of Applied Microbiology, vol.7, issue.2, pp.289-301, 2012.
DOI : 10.1111/j.1365-2672.2011.05211.x

L. Gram, J. Melchiorsen, and J. Bruhn, Antibacterial Activity of Marine Culturable Bacteria Collected from a Global Sampling of Ocean Surface Waters and Surface Swabs of Marine Organisms, Marine Biotechnology, vol.4, issue.4, pp.439-451, 2010.
DOI : 10.1007/s10126-009-9233-y

L. Romanenko, M. Uchino, N. Kalinovskaya, and V. Mikhailov, Isolation, phylogenetic analysis and screening of marine mollusc-associated bacteria for antimicrobial, hemolytic and surface activities, Microbiological Research, vol.163, issue.6, pp.633-644, 2008.
DOI : 10.1016/j.micres.2006.10.001

D. Pinkerton, M. Banwell, M. Garson, N. Kumar, D. Moraes et al., Antimicrobial and Cytotoxic Activities of Synthetically Derived Tambjamines C and E???-???J, BE-18591, and a Related Alkaloid from the Marine Bacterium Pseudoalteromonas tunicata, Chemistry & Biodiversity, vol.175, issue.5, pp.1311-1324, 2010.
DOI : 10.1002/cbdv.201000030

A. Murphy, D. Fukuda, Z. Song, J. Hothersall, R. Cox et al., Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390, Angewandte Chemie International Edition, vol.48, issue.14, pp.3271-3274, 2011.
DOI : 10.1002/anie.201007029

G. Hayashida-soiza, A. Uchida, N. Mori, Y. Kuwahara, and Y. Ishida, strain, Journal of Applied Microbiology, vol.11, issue.5, pp.1672-1677, 2008.
DOI : 10.1111/j.1365-2672.2008.03878.x

N. Kalinovskaya, E. Ivanova, Y. Alexeeva, N. Gorshkova, T. Kuznetsova et al., Low-Molecular-Weight, Biologically Active Compounds from Marine Pseudoalteromonas Species, Current Microbiology, vol.48, issue.6, pp.441-446, 2004.
DOI : 10.1007/s00284-003-4240-0

A. Longeon, J. Peduzzi, M. Barthélemy, S. Corre, J. Nicolas et al., Purification and Partial Identification of Novel Antimicrobial Protein from Marine Bacterium Pseudoalteromonas Species Strain X153, Marine Biotechnology, vol.64, issue.6, pp.633-641, 2004.
DOI : 10.1007/s10126-004-3009-1

URL : https://hal.archives-ouvertes.fr/hal-00145808

D. Gómez, E. Espinosa, M. Bertazzo, P. Lucas-elío, F. Solano et al., The macromolecule with antimicrobial activity synthesized by Pseudoalteromonas luteoviolacea strains is an l-amino acid oxidase, Applied Microbiology and Biotechnology, vol.44, issue.6, pp.925-930, 2008.
DOI : 10.1007/s00253-008-1499-x

M. Yu, J. Wang, K. Tang, X. Shi, S. Wang et al., Purification and characterization of antibacterial compounds of Pseudoalteromonas flavipulchra JG1, Microbiology, vol.158, issue.Pt_3, pp.835-842, 2011.
DOI : 10.1099/mic.0.055970-0

S. Duquesne, D. Destoumieux-garzón, J. Peduzzi, and S. Rebuffat, Microcins, gene-encoded antibacterial peptides from enterobacteria, Natural Product Reports, vol.42, issue.130, pp.708-734, 2007.
DOI : 10.1039/b516237h

URL : https://hal.archives-ouvertes.fr/hal-00146730

D. Vuyst, L. Leroy, and F. , Bacteriocins from Lactic Acid Bacteria: Production, Purification, and Food Applications, Journal of Molecular Microbiology and Biotechnology, vol.13, issue.4, pp.194-199, 2007.
DOI : 10.1159/000104752

M. Shnit-orland and A. Kushmaro, Coral mucus-associated bacteria: a possible first line of defense, FEMS Microbiology Ecology, vol.67, issue.3, pp.371-380, 2009.
DOI : 10.1111/j.1574-6941.2008.00644.x

E. Kvennefors, E. Sampayo, C. Kerr, G. Vieira, G. Roff et al., Regulation of Bacterial Communities Through Antimicrobial Activity by the Coral Holobiont, Microbial Ecology, vol.9, issue.11, pp.605-618, 2012.
DOI : 10.1007/s00248-011-9946-0