Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a Nasutitermes sp. termite. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Natural Products Année : 2013

Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a Nasutitermes sp. termite.

Charlotte Nirma
  • Fonction : Auteur
Didier Stien

Résumé

Defense mutualisms between social insects and microorganisms have been described in the literature. The present article describes the discovery of a Pseudallescheria boydii strain isolated from Nasutitermes sp. The microbial symbiont produces two antifungal metabolites: tyroscherin and N-methyltyroscherin, a compound not previously described in the literature. Methylation of tyroscherin has confirmed the structure of N-methyltyroscherin. Both compounds are effective antifungal agents with favorable selectivity indices for Candida albicans and Trichophyton rubrum.

Domaines

Chimie organique
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Dates et versions

hal-00856773 , version 1 (02-09-2013)

Identifiants

Citer

Charlotte Nirma, Véronique Eparvier, Didier Stien. Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a Nasutitermes sp. termite.. Journal of Natural Products, 2013, 76 (5), pp.988-91. ⟨10.1021/np4001703⟩. ⟨hal-00856773⟩
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