Biological effects and equivalent doses in radiotherapy: a software solution

Abstract : The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding the delivered doses or any future prescriptions relating to treatment changes. We therefore propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model). The methodology used draws from several sources: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames. The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to the equivalent dose computed using standard calculators in seven French radiotherapy centers.
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Contributor : Cyril Voyant <>
Submitted on : Thursday, August 22, 2013 - 7:55:48 PM
Last modification on : Tuesday, August 20, 2019 - 3:00:05 PM
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  • HAL Id : hal-00853583, version 1
  • ARXIV : 1308.5906



Cyril Voyant, Daniel Julian, Rudy Roustit, Katia Biffi, Celine Lantieri Marcovici. Biological effects and equivalent doses in radiotherapy: a software solution. Reports of Practical Oncology & Radiotherapy, Elsevier, 2013. ⟨hal-00853583⟩



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