Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis.

Karine Le Roux (1) , Laurent Kodjikian (2) , Romain Marignier (3) , Julien Bancel (4, 5) , Christiane Broussolle (6) , Pascal Sève (6)

1 hospices civils de lyon
2 Biomatériaux et remodelages matriciels
3 Pierre Wertheimer
4 Hôpital Edouard Herriot [CHU - HCL]
5 UCBL - Université Claude Bernard Lyon 1
6 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon

PURPOSE: To assess the value of lumbar punctures in adult patients with unexplained intermediate uveitis (IU). METHODS: Retrospective study of 17 patients with unexplained IU. All the patients underwent physical examination, complete laboratory tests, and cerebrospinal MRI. RESULTS: Out of the 12 patients who underwent a lumbar puncture, six had oligoclonal bands and/or increased IgG index. CONCLUSION: Intrathecal synthesis of immunoglobulins is not rare in patients with unexplained IU. A longer follow-up is mandatory to determine whether intrathecal immunoglobulins synthesis has a predictive value for subsequent progression to multiple sclerosis.

Domaines: Cancer

Karine Le Roux, Laurent Kodjikian, Romain Marignier, Julien Bancel, Christiane Broussolle, et al.. Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis.. Ocular Immunology and Inflammation, 2011, 19 (1), pp.26-31. ⟨10.3109/09273948.2010.505357⟩. ⟨hal-00850120⟩