Biofunctional micellar nanoparticles from peptide-b-polymer chimeras

Abstract : We describe the precision synthesis and characterization of amphiphilic peptide-b-polymer chimeras encoding, at the molecular level, self-assembly properties and biological functions, presently cell membrane penetrating motifs (Tat peptide). Self-assembled micellar nanoparticles obtained from a series of Tat-b-poly(trimethylene carbonate) (Tat-b-PTMC) chimeras with tunable hydrophilic fractions were finely characterized in order to establish chimera-nanoparticle structure relationships. Well-defined nanoparticles with diameters ranging from 22 to 40 nm could be obtained by direct self-assembly in buffer.
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Submitted on : Thursday, July 18, 2013 - 6:17:15 PM
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Charlotte Drappier, Anne-Laure Wirotius, Katell Bathany, Emmanuel Ibarboure, Olivia Condassamy, et al.. Biofunctional micellar nanoparticles from peptide-b-polymer chimeras. Polymer Chemistry, Royal Society of Chemistry - RSC, 2013, 4 (6), pp.2011-2018. ⟨10.1039/c2py21044d⟩. ⟨hal-00846289⟩



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