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Innate pro-B cell progenitors protect against type 1 diabetes by regulating autoimmune effector T cells.

Abstract : Diverse hematopoietic progenitors, including myeloid populations arising in inflammatory and tumoral conditions and multipotent cells, mobilized by hematopoietic growth factors or emerging during parasitic infections, display tolerogenic properties. Innate immune stimuli confer regulatory functions to various mature B-cell subsets but immature B-cell progenitors endowed with suppressive properties per se or after differentiating into more mature regulatory B cells remain to be characterized. Herein we provide evidence for innate pro-B cells (CpG-proBs) that emerged within the bone marrow both in vitro and in vivo upon Toll-like receptor-9 activation and whose adoptive transfer protected nonobese diabetic mice against type 1 diabetes (T1D). These cells responded to IFN-gamma released by activated effector T cells (Teffs), by up-regulating their Fas ligand (FasL) expression, which enabled them to kill Teffs through apoptosis. In turn, IFN-gamma derived from CpG-proBs enhanced IFN-gamma while dramatically reducing IL-21 production by Teffs. In keeping with the crucial pathogenic role played by IL-21 in T1D, adoptively transferred IFN-gamma-deficient CpG-proBs did not prevent T1D development. Additionally, CpG-proBs matured in vivo into diverse pancreatic and splenic suppressive FasL(high) B-cell subsets. CpG-proBs may become instrumental in cell therapy of autoimmune diseases either on their own or as graft complement in autologous stemcell transplantation
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https://hal.archives-ouvertes.fr/hal-00845005
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Submitted on : Tuesday, July 16, 2013 - 12:07:49 PM
Last modification on : Tuesday, May 31, 2022 - 10:20:13 AM

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R. Montandon, S. Korniotis, E. Layseca-Espinosa, C. Gras, J. Megret, et al.. Innate pro-B cell progenitors protect against type 1 diabetes by regulating autoimmune effector T cells.. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110, pp.E2199-E2208. ⟨10.1073/pnas.1222446110⟩. ⟨hal-00845005⟩

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