Mannose-functionalized porous silica-coated magnetic nanoparticles for two-photon imaging or PDT of cancer cells

Abstract : An original fluorophore engineered for two-photon excitation or a porphyrin derivative were entrapped in the silica shell of magnetic porous silica nanoparticles during the synthesis of the silica moiety without damaging the structure of the organic part. The mild conditions involved allowed obtaining microporous or mesoporous silica magnetic nanoparticles, respectively. Mannose was grafted on the surface of the nanoparticles to target MCF-7 breast cancer cells. The studies of magnetic properties of these hybrid nanoparticles showthat they present a blocking temperature at 190 K. The nano-objects designed with the twophoton fluorophore were efficient for two-photon imaging of MCF-7 cancer cells, whereas the nanoobjects with the photosensitizer efficiently killed cancer cells. The presence of the mannose moiety was demonstrated to improve both imaging and therapy properties.
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Journal of Nanoparticle Research, Springer Verlag, 2013, 15, pp.1602-1609. 〈10.1007/s11051-013-1602-9〉
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https://hal.archives-ouvertes.fr/hal-00841213
Contributeur : Brigitte Carles <>
Soumis le : jeudi 4 juillet 2013 - 10:53:19
Dernière modification le : samedi 22 décembre 2018 - 19:26:46

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Marine Perrier, Magali Gary-Bobo, Lenaic Lartigue, David Brevet, Alain Morère, et al.. Mannose-functionalized porous silica-coated magnetic nanoparticles for two-photon imaging or PDT of cancer cells. Journal of Nanoparticle Research, Springer Verlag, 2013, 15, pp.1602-1609. 〈10.1007/s11051-013-1602-9〉. 〈hal-00841213〉

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