SYNTHESIS OF ANALOGUES OF MAKALUVAMINE A

S. Bouclé (1) , J. Guillard (2)

1 Université Francois Rabelais [Tours]
2 OrgaSynth - Synthèse organique [E5 – IC2MP équipe 5]

A new and efficient synthesis of tricyclic pyridoquinonoxalinone 1 an analog of Makaluvamine A and its intermediates 2 and 3 has been developed starting from 5,8-dimethoxy-4,4-dimethyl[1,2,3,4]tetrahydroquinoline 4. The synthesis was accomplished in 11 steps and 4% overall yield from commercially available 2,5-dimethoxyaniline.

Domaines: Catalyse; Chimie organique; Autre

S. Bouclé, J. Guillard. SYNTHESIS OF ANALOGUES OF MAKALUVAMINE A. Heterocycles, 2012, 85 (3), pp.677-688. ⟨10.3987/COM-11-12414⟩. ⟨hal-00838498⟩