Time-domain reflectance diffuse optical tomography with Mellin-Laplace transform for experimental detection and depth localization of a single absorbing inclusion.

Agathe Puszka (1) , Lionel Hervé (1) , Anne Planat-Chrétien (1) , Anne Koenig (1) , Jacques Derouard (2) , Jean-Marc Dinten (1)

1 CEA-LETI - Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information
2 MOTIV-LIPhy - Matériaux, Optique et Techniques Instrumentales pour le Vivant

We show how to apply the Mellin-Laplace transform to process time-resolved reflectance measurements for diffuse optical tomography. We illustrate this method on simulated signals incorporating the main sources of experimental noise and suggest how to fine-tune the method in order to detect the deepest absorbing inclusions and optimize their localization in depth, depending on the dynamic range of the measurement. To finish, we apply this method to measurements acquired with a setup including a femtosecond laser, photomultipliers and a time-correlated single photon counting board. Simulations and experiments are illustrated for a probe featuring the interfiber distance of 1.5 cm and show the potential of time-resolved techniques for imaging absorption contrast in depth with this geometry.

Domaines: Optique [physics.optics]; Imagerie

Agathe Puszka, Lionel Hervé, Anne Planat-Chrétien, Anne Koenig, Jacques Derouard, et al.. Time-domain reflectance diffuse optical tomography with Mellin-Laplace transform for experimental detection and depth localization of a single absorbing inclusion.. Biomedical optics express, 2013, 4 (4), pp.569-83. ⟨10.1364/BOE.4.000569⟩. ⟨hal-00832484⟩