Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.

Abstract : Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
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Nature Neuroscience, Nature Publishing Group, 2013, 16 (7), pp.845-7. <10.1038/nn.3401>
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Contributeur : Olivier Meste <>
Soumis le : mercredi 29 mai 2013 - 20:51:46
Dernière modification le : lundi 19 septembre 2016 - 11:56:20

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Grégory Conductier, Frédéric Brau, Angèle Viola, Fanny Langlet, Navean Ramkumar, et al.. Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.. Nature Neuroscience, Nature Publishing Group, 2013, 16 (7), pp.845-7. <10.1038/nn.3401>. <hal-00827897>

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