Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.

Abstract : Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-00827897
Contributor : Olivier Meste <>
Submitted on : Wednesday, May 29, 2013 - 8:51:46 PM
Last modification on : Monday, November 5, 2018 - 3:52:01 PM

Identifiers

Citation

Grégory Conductier, Frédéric Brau, Angèle Viola, Fanny Langlet, Navean Ramkumar, et al.. Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.. Nature Neuroscience, Nature Publishing Group, 2013, 16 (7), pp.845-7. ⟨10.1038/nn.3401⟩. ⟨hal-00827897⟩

Share

Metrics

Record views

409