Abstract : Case-Based Reasoning (CBR) and interpolation tools can provide solutions to unknown problems by adapting solutions from other problems already solved. We propose a generic approach using an interpolation tool during the CBR-adaptation phase. The application EquiVox, which attempts to design three dimensional representations of human organs according to external measurements, was modelled. It follows the CBR-cycle with its adaptation tool based on Artificial Neural Networks and its performances are evaluated and discussed. The results show that this adaptation tool meets the requirements of radiation protection experts who use such prototypes and also what the limits are of such tools in CBR-adaptation. When adaptations are guided by experience grained through trial and error by experts, interpolation tools become well-suited methods for automatically and quickly providing adaptation strategies and knowledge through training phases.