Skip to Main content Skip to Navigation
Journal articles

Blood-feeding and immunogenic Aedes aegypti saliva proteins.

Abstract : Mosquito-transmitted pathogens pass through the insect's midgut (MG) and salivary gland (SG). What occurs in these organs in response to a blood meal is poorly understood, but identifying the physiological differences between sugar-fed and blood-fed (BF) mosquitoes could shed light on factors important in pathogens transmission. We compared differential protein expression in the MGs and SGs of female Aedes aegypti mosquitoes after a sugar- or blood-based diet. No difference was observed in the MG protein expression levels but certain SG proteins were highly expressed only in BF mosquitoes. In sugar-fed mosquitoes, housekeeping proteins were highly expressed (especially those related to energy metabolism) and actin was up-regulated. The immunofluorescence assay shows that there is no disruption of the SG cytoskeletal after the blood meal. We have generated for the first time the 2-DE profiles of immunogenic Ae. aegypti SG BF-related proteins. These new data could contribute to the understanding of the physiological processes that appear during the blood meal.
Document type :
Journal articles
Complete list of metadatas
Contributor : David Biron <>
Submitted on : Monday, May 6, 2013 - 1:07:06 PM
Last modification on : Thursday, December 3, 2020 - 5:00:02 PM

Links full text



Ladawan Wasinpiyamongkol, Sirilaksana Patramool, Natthanej Luplertlop, Pornapat Surasombatpattana, Souleymane Doucoure, et al.. Blood-feeding and immunogenic Aedes aegypti saliva proteins.. Proteomics, Wiley-VCH Verlag, 2010, 10 (10), pp.1906-16. ⟨10.1002/pmic.200900626⟩. ⟨hal-00820653⟩



Record views