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Neuronal activity correlated with checking behaviour in the subthalamic nucleus of patients with obsessive-compulsive disorder.

Pierre Burbaud 1 Anne-Hélène Clair Nicolas Langbour 2 Sara Fernandez-Vidal 3, 4 Michel Goillandeau Thomas Michelet Eric Bardinet 3, 4, 5 Isabelle Chéreau 6 Franck Durif 7 Mircea Polosan 8 Stephan Chabardès 9 Denys Fontaine 10 Marie-Noelle Magnié-Mauro 11 Jean-Luc Houeto 12, 13 Benoît Bataille 12 Bruno Millet 14, 15 Marc Vérin 16 Nicolas Baup 17 Marie-Odile Krebs 17 Philippe Cornu 18 Antoine Pelissolo 19 Christophe Arbus 20 Marion Simonetta-Moreau 21 Jérôme Yelnik 3, 22 Marie-Laure Welter 3, 22, 23 Luc Mallet 3, 22
Abstract : Doubt, and its behavioural correlate, checking, is a normal phenomenon of human cognition that is dramatically exacerbated in obsessive-compulsive disorder. We recently showed that deep brain stimulation in the associative-limbic area of the subthalamic nucleus, a central core of the basal ganglia, improved obsessive-compulsive disorder. To understand the physiological bases of symptoms in such patients, we recorded the activity of individual neurons in the therapeutic target during surgery while subjects performed a cognitive task that gave them the possibility of unrestricted repetitive checking after they had made a choice. We postulated that the activity of neurons in this region could be influenced by doubt and checking behaviour. Among the 63/87 task-related neurons recorded in 10 patients, 60% responded to various combinations of instructions, delay, movement or feedback, thus highlighting their role in the integration of different types of information. In addition, task-related activity directed towards decision-making increased during trials with checking in comparison with those without checking. These results suggest that the associative-limbic subthalamic nucleus plays a role in doubt-related repetitive thoughts. Overall, our results not only provide new insight into the role of the subthalamic nucleus in human cognition but also support the fact that subthalamic nucleus modulation by deep brain stimulation reduced compulsive behaviour in patients with obsessive-compulsive disorder.
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https://hal.inria.fr/hal-00817570
Contributor : Olivier Colliot <>
Submitted on : Wednesday, April 24, 2013 - 7:48:38 PM
Last modification on : Friday, June 26, 2020 - 10:20:04 AM

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Pierre Burbaud, Anne-Hélène Clair, Nicolas Langbour, Sara Fernandez-Vidal, Michel Goillandeau, et al.. Neuronal activity correlated with checking behaviour in the subthalamic nucleus of patients with obsessive-compulsive disorder.. Brain - A Journal of Neurology , Oxford University Press (OUP), 2013, 136 (Pt 1), pp.304-17. ⟨10.1093/brain/aws306⟩. ⟨hal-00817570⟩

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