Nucleotide sequence of SHV-2 beta-lactamase gene.

A. Garbarg-Chenon (1) , V. Godard (2) , R. Labia , J. C. Nicolas

1 UPMC - Université Pierre et Marie Curie - Paris 6
2 LGENS - Laboratoire de géologie de l'ENS

The nucleotide sequence of plasmid-mediated beta-lactamase SHV-2 from Salmonella typhimurium (SHV-2pHT1) was determined. The gene was very similar to chromosomally encoded beta-lactamase LEN-1 of Klebsiella pneumoniae. Compared with the sequence of the Escherichia coli SHV-2 enzyme (SHV-2E.coli) obtained by protein sequencing, the deduced amino acid sequence of SHV-2pHT1 differed by three amino acid substitutions.

Domaines: Chimie organique

A. Garbarg-Chenon, V. Godard, R. Labia, J. C. Nicolas. Nucleotide sequence of SHV-2 beta-lactamase gene.. Antimicrobial Agents and Chemotherapy, 1990, 34 ((7)), pp.1444-6. ⟨hal-00814764⟩